Research work

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Dr. BAI Jie


Bai Jie M.D/Ph.D  

Education and working:

2005.10--- now  Professor, vice dean of medical school, Kunming University of

Science and Technology

2003.6--- 2005  Postdoc training, Medical Department of Virginia University, USA

1999.4--- 2003  Medicine Doctor, Medical Department of Kyoto University, Japan

1988.9--- 1997    Doctor-in-charge, Neurology Department, First people hospital of Yunnan Province

1983.9---1988     Bachelor, Kunming Medical School, Kunming


1. Jia JJ, Zeng XS, Li Y, Ma S, Bai J. Ephedrine induced thioredoxin-1 expression through β-adrenergic receptor/cyclic AMP/protein kinase A/dopamine- and cyclic AMP-regulated phosphoprotein signaling pathway.

Cell Signal. 2013 Feb 14; 25(5):1194-1201

2. Lv T, Wang SD, Bai J. Thioredoxin-1 was required for CREB Activity by Methamphetamine in Rat Pheochromocytoma Cells. Cell Mol Neurobiol. 2012 Dec 13. [Epub ahead of print]

3. Luo FC, Zhao L, Deng J, Liang M, Zeng XS, Liu H, Bai J. Geranylgeranylacetone protects against morphine-induced hepatic and renal damage in mice. Mol Med Report. 2013; 7(2): 694-700

4. Song J, Dong X, Chen Y, Chen G, Liang H, Nakamura H, Yodoi J, Bai J

The expression of thioredoxin-1 in preterm delivery placenta. Redox Rep. 2012; 17(5):187-93.

5. Luo FC, Feng YM, Zhao L, Li K, Wang SD, Song JY, Bai J. Thioredoxin-1 expression regulated by morphine in SH-SY5Y cells. Neurosci Lett. 2012 8; 523(1):50-5.

6. Luo FC, Zhou J, Lv T, Qi L, Wang SD, Nakamura H, Yodoi J, Bai J.

Induction of endoplasmic reticulum stress and the modulation of thioredoxin-1 in formaldehyde-induced neurotoxicity. Neurotoxicology. 2012; 33(3):290-8.

7.Luo, F. C.; Qi, L.; Lv, T.; Wang, S. D.; Liu, H.; Nakamura, H.; Yodoi, J.; Bai, J. Geranylgeranylacetone protects mice against morphine-induced hyperlocomotion, rewarding effect, and withdrawal syndrome. Free Radic Biol Med 2012;52: 1218-1227.

8.Wang, S. D.; Luo, F. C.; Chen, Y.; Qi, L.; Bai, J.      1-methyl-4-phenylpyridinium ion induces endoplasmic reticulum stress through glycogen synthase kinase-3 beta activation in PC12 cells. Neural Regen Res 2011; 6:805-810.

9.Luo, F. C.; Wang, S. D.; Qi, L.; Song, J. Y.; Lv, T.; Bai, J. Protective effect of panaxatriol saponins extracted from Panax notoginseng against MPTP-induced neurotoxicity in vivo. J Ethnopharmacol 2011; 133:448-453.

10.Luo, F. C.; Wang, S. D.; Li, K.; Nakamura, H.; Yodoi, J.; Bai, J. Panaxatriol saponins extracted from Panax notoginseng induces thioredoxin-1 and prevents 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. J Ethnopharmacol 2010;127:419-423.

11. Bai, J.; Nakamura, H.; Kwon, Y. W.; Tanito, M.; Ueda, S.; Tanaka, T.; Hattori, I.; Ban, S.; Momoi, T.; Kitao, Y.; Ogawa, S.; Yodoi, J. Does thioredoxin-1 prevent mitochondria- and endoplasmic reticulum-mediated neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine? Antioxid Redox Signal 2007; 9:603-608.

12.Tanito, M.; Kwon, Y. W.; Kondo, N.; Bai, J.; Masutani, H.; Nakamura,  H.; Fujii, J.; Ohira, A.; Yodoi, J. Cytoprotective effects of geranylgeranylacetone against retinal photooxidative damage. J Neurosci 2005; 25:2396-2404.

13.Masutani, H.; Bai, J.; Kim, Y. C.; Yodoi, J. Thioredoxin as a neurotrophic cofactor and an important regulator of neuroprotection. Mol Neurobiol 2004; 29:229-242.

14.Hattori, I.; Takagi, Y.; Nakamura, H.; Nozaki, K.; Bai, J.; Kondo, N.; Sugino, T.; Nishimura, M.; Hashimoto, N.; Yodoi, J. Intravenous administration of thioredoxin decreases brain damage following transient focal cerebral ischemia in mice. Antioxid Redox Signal 2004; 6:81-87.

15. Bai, J.; Nakamura, H.; Ueda, S.; Kwon, Y. W.; Tanaka, T.; Ban, S.; Yodoi, J. Proteasome-dependent degradation of cyclin D1 in 1-methyl-4-phenylpyridinium ion (MPP+)-induced cell cycle arrest. J Biol Chem 2004; 279:38710-38714.

16. Bai, J.; Nakamura, H.; Kwon, Y. W.; Hattori, I.; Yamaguchi, Y.; Kim, Y. C.; Kondo, N.; Oka, S.; Ueda, S.; Masutani, H.; Yodoi, J. Critical roles of thioredoxin in nerve growth factor-mediated signal transduction and neurite outgrowth in PC12 cells. J Neurosci 2003; 23:503-509.

17. Hattori, I.; Takagi, Y.; Nozaki, K.; Kondo, N.; Bai, J.; Nakamura, H.; Hashimoto, N.; Yodoi, J. Hypoxia-ischemia induces thioredoxin expression and nitrotyrosine formation in new-born rat brain. Redox Rep2002; 7:256-259.

18. Bai, J.; Nakamura, H.; Hattori, I.; Tanito, M.; Yodoi, J. Thioredoxin suppresses 1-methyl-4-phenylpyridinium-induced neurotoxicity in rat PC12 cells. Neurosci Lett 2002; 321:81-84.

19. Nakamura, H.; Herzenberg, L. A.; Bai, J.; Araya, S.; Kondo, N.; Nishinaka, Y.; Yodoi, J. Circulating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis. Proc Natl Acad Sci U S A2001; 98:15143-15148.

20. Dekigai, H.; Nakamura, H.; Bai, J.; Tanito, M.; Masutani, H.; Hirota, K.; Matsui, H.; Murakami, M.; Yodoi, J. Geranylgeranylacetone promotes induction and secretion of thioredoxin in gastric mucosal cells and peripheral blood lymphocytes. Free Radical Res 2001; 35:23-30.

21. Hirota K, Nakamura H, Arai T, Ishii H, Bai J, Itoh T, Fukuda K, Yodoi J.

Geranylgeranylacetone enhances expression of thioredoxin and suppresses ethanol-induced cytotoxicity in cultured hepatocytes. Biochem Biophys Res Commun. 2000; 275(3):825-3

22.  Nakamura H, Bai J, Nishinaka Y, Ueda S, Sasada T, Ohshio G, Imamura M, Takabayashi A, Yamaoka Y, Yodoi J. Expression of thioredoxin and glutaredoxin, redox-regulating proteins, in pancreatic cancer. Cancer Detect Prev. 2000; 24(1):53-60.

Research Funding:

1.      National Natural Science Foundation of China (nos. 81160162,):

2.  National Natural Science Foundation of China (U1202227)

3.  The Key Laboratory of Medical Neurobiology, Kunming University of Science and Technology, Yunnan, China.