Research work

Home >Research work >Academic staff

Dr. ZHANG Jihong

Update:2017-05-24

Dr Jihong Zhang,  Professor,  PhDPharm

Research: I am involved in cancer molecular pharmacology, with interests focused on characterization and development of potential anticancer agents.

1).Screening the anit-cancer agents and investigating the mechanism of action

2).DNA damage and repair in the anticancer drug resistance, developing anti-angiogenesis and targeting mutant p53 agents.

Contact informationzhjihong2000@126.com

Education  

2007.01-2010.01  PhD , School of Pharmacy, University of Nottingham, UK

1992.09-1996.07  Bsc (pharmaceutics), ShenYang Pharmaceutical University, P.R.China 

 Employment                                                                          

2012.04- present   Professor, Faculty of Medicine, Kunming University of Science and TechnologyKunming, China

2010.04-2012.08  Associate professor, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China

  2007.01- 2010.01  Pharmacologist, Pharminox Ltd, UK Oncology R&D Company

2005.09-2006.09  Research Associate, Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham

2004.06-2005.06  Academic Visiting Scientist, Medicinal Chemistry Group, School of Pharmacy, University of Nottingham, UK

2000.09-2004.12  Head of the formulation group, senior pharmacist in the First People’s Hospital of Yunnan Province, China

2000.03-2000.09  Placement in clinical pharmacy, Zhongshan Medical University, Guangzhou, China

1999.01-2000.02  Head of the outpatient dispensary pharmacy in the First People’s Hospital of Yunnan province, China

1996.07-1999.01 pharmacist, The First People’s Hospital of Yunnan Province        

Grants hold

1. Mechanism of anti-tumor action of Buxus alkaloids by degradation of mutant p53. (National Natural Science Foundation of China, NSFC, 81560601)

2. Mechanism of action of temozolomideanalogues which overcome O6-methylguaine methyltransferase. (National Natural Science Foundation of China, NSFC, 81260501)

3. Mechanism of action of opoid receptor δμκ triple activation. (NSFC, 81173029)

 4. Design, Synthesis and Antitumor Activity Study of Novel Anti-angiogenic Tyrosine Kinase Inhibitors, NSFC-Yunnan joint grants, U1202221

Patent:

1.                       STEVENS, Malcolm, Francis; Graham COUSIN, David;  JENNINGS, Sharon;  McCARROLL, Andrew, James; WILLIAMS , John, Gareth; HUMMERSONE , Marc, Geoffery; ZHANG, Jihong.3-Substituted- 4- Oxo- 3,4- Dihydro- Imidazo [5,1- d] [1,2,3,5-Tetrazine-8- Carboxylic Acid Amides and Their Use.International Patent Application No PCT/GB2008/004140 filed 16 December 2008.

Publications

1.         Zhikuan Yang, Danping Wei,?Xiaoli Dai, Malcolm FG Stevens, Tracey D Bradshaw,? Ying Luo and Jihong Zhang. C8-Substituted Temozolomide Analogs Overcome O6-Methylguanine-DNA Methyltransferase and Mismatch Repair Precipitating Apoptotic Cancer Cell Death. Neuro-Oncology 2017. Vol. 2 No. 1: 2 DOI: 10.21767/2572-0376.100018IF 7.37

2.         Xiaoli Dai, Jing Liu, Yin Nian, Ming-HuaQiu, Ying Luo, Jihong Zhang*. A novel cycloartanetriterpenoid from Cimicifuga induces apoptotic and autophagic cell death in human colon cancer HT-29 cells.Oncol Rep.2017 Apr;37(4):2079-2086. doi: 10.3892/or.2017.5444. Epub 2017 Feb 14. IF 2.49

3.         Jing Liu, Tongyang Liu, HancunMou, Chao Huang, Shengjiao Yan, Jun Lin, Ying Luo and Jihong Zhang. An Isoquinolin-1(2H)-Imine Derivative Induces Cell Death via Generation of Reactive Oxygen Species and Activation of JNK in Human A549 Cancer Cells. Journal of Cellular Biochemistry.

4.         Fu-Chao Yu, Xin-Rong Lin, Zhi-Cheng Liu, Ji-Hong Zhang,*Fei-Fei Liu, Wei Wu, Yu-Lu Ma, Wen-Wen Qu, Sheng-Jiao Yan,* and Jun Lin* Beyond the Antagonism: Self-Labeled Xanthone Inhibitors as Modeled “Two-in-One” Drugs in Cancer Therapy. ACS Omega 2017, 2, 873?889.  DOI: 10.1021/acsomega.6b00545

5.         YafeiGuo, Yushun Zhang, Jiuling Li, Fen Zhao, Yang Liu, Min Su, Yubo Jiang, Yuqi Liu, Jihong Zhang,* Bo Yang,* and Rui Yang* Inclusion Complex of Podophyllotoxin with γ-Cyclodextrin: Preparation, Characterization, Anticancer Activity, Water-Solubility and Toxicity  Chin. J. Chem. 2016, 34, 425—431

6.         YufengRen, Ying Liu, RaomeiNiu, XialiLiao ,Jihong Zhang*, Bo Yang. Host-guest inclusion system of oleanolic acid with methyl-b- cyclodextrin: Preparation, characterization and anticancer activity. Journal of Molecular Structure 1117 (2016) 1-7.

7.         YufengRen, Ying Liu, Zhikuan Yang, RaomeiNiu, Kai Gao, Bo Yang, Xiali Liao, Jihong Zhang. Solid Inclusion Complexes of Oleanolic Acid with Amino-appended β- Cyclodextrins (ACDs): Preparation, Characterization, Water Solubility and Anticancer Activity. Materials Science & Engineering C[J], 2016, 05(022)

8.         Zhu MLiu TZhang JJia STang WLuo Y. Association between rs1344706 of ZNF804A and schizophrenia: a meta-analysisGenomics Proteomics Bioinformatics. 2014 Dec;12(6):292-6

9.         Jing Liu, Wenhui Huang, Ruoyu Zhou, ShutingJia, Wenru Tang, Ying Luo, and Jihong Zhang*. Bisphosphonates in the Treatment of Patients With Metastatic Breast, Lung, and Prostate Cancer. MedicineVolume 94, Number 46, November 2015.1-5.

10.     Liu JTang WSang LDai XWei DLuo YZhang J.Milk, Yogurt, and Lactose Intake and Ovarian Cancer Risk: A Meta-Analysis.NutrCancer.2015; 67(1):68-72

11.     Yin NianJing YangTong-Yang LiuYing LuoJi-Hong Zhang*, Ming-HuaQiu. New Anti-angiogenic Leading Structure Discovered in the Fruit of Cimicifugayunnanensis. Scientific Reports 20155:9026,1-7.

12.     Haiyu Yang, Danping Wei,Kunxian Yang,WenruTang,YingLuo,Jihong Zhang*. The Prognosis of MGMT Promoter Methylation in Glioblastoma Patients of Different Race: A Meta-analysis. Neuroche Res 2014392277-2287.

13.     Jihong Zhang, Marc Hummersone, Charles S Matthews, Malcolm FG Stevensand Tracey D Bradshaw. N3-Substituted temozolomide analogs overcome methylguanine DNA methyltransferase and mismatch repair precipitating apoptotic and autophagic cancer cell death.Oncology2015;88:28–48

14.     Ai Zhipeng, NingXianming, Shou Tao, Tang wenru andZhang Jihong*. Association of interleukin-6 promoter polymorphism with knee osteoarthritis: a meta-analysis.Chin Med J2014;127(13)

15.     Rui Yang, Jing-Bo Chen, Chuan-Fan Xiao, Zhi-Cheng Liu, Zhan-Yong Gao,Sheng-Jiao Yan,Ji-Hong Zhang*, Hong-Bin Zhang, Jun Lin. Inclusion complex of GA-13316 withβ-cyclodextrin: Preparation, characterization, molecular modeling, andin vitroevaluation. Carbohydrate Polymers, 2014, 111 655–662.

16.     Lei FengShi-yanNianJihongzhang*.The GG genotype oftelomerase reverse transcriptase at genetic locus rs2736100 is associated with human atherosclerosis risk in the Han Chinese population. PloS One, 2014, 9 (1), 85719.

17.     Yi-Chuan Zhang, Zhi-Cheng Liu, Rui Yang,Ji-Hong Zhang, Sheng-Jiao Yan and Jun Lin. Regioselective construction of 1,3-diazaheterocycle fused [1,2-a] [1,8] naphthyridine derivatives via cascade reaction of quinolines with heterocyclic ketene aminals: a joint experimental–computational approach.Org. Biomol. Chem., 2013, 11, 7276–7288

 

18.     Liang XiJian-Qiang Zhang,Zhi-Cheng Liu,Ji-Hong ZhangJu-Fang Yan,Yi JinJun Lin.Novel 5-anilinoquinazoline-8-nitro derivatives as inhibitors of VEGFR-2 tyrosine kinase: synthesis, biological evaluation and molecular docking.Org. Biomol. Chem., 2013,11, 4367-4378

 

19.     Sheng-Jiao Yan, Ying Dong, QiongPeng, Yin-Xin Fan,Ji-Hong Zhang*, Jun Lin. Synthesis of polyhalo 2-aryl-4-aminoquinazoline and 3-amino-indazoles as anticancer agents.RSC Advances.2013, 3, 5563-5569

 

20.     Bo Yang, Yu-Lin Zhao, Xia Yang, Xia-Li Liao, Jian Yang,Ji-Hong Zhang,Chuan-Zhu Gao. Scutellarin-cyclodextrin conjugates: Synthesis, characterization and anticancer activity.Carbohydrate Polymers.2013, 92, 1308– 1314

 

21.     Zhang J, Stevens MF, Bradshaw TD. Temozolomide: Mechanisms of Action, Repair and Resistance.Curr Mol Pharmacol.2012,5,102-114.

 

22.     Zhang J, Stevens MF, Hummersone M, Madhusudan S, Charles Laughton, Bradshaw TD. Certain ImidazotetrazinesEscape  O6- Methylguanine- DNA- methyltransferase and Mismatch Repair.Oncology.2011;80:195-207.

 

23.     Zhang J,Stevens MF,Laughton CA,Madhusudan S,Bradshaw TD.Acquired resistance to Temozolomide in glioma cell lines: molecular mechanisms and potential translational applications.Oncology.2010Mar 31;78(2):103-114.

 

24.     Zhang JH, Pearson T, Matharoo-Ball B, Ortori CA, Warren AY, Khan R, Barrett DA.Quantitative profiling of epoxyeicosatrienoic, hydroxyeicosatetraenoic, and dihydroxyeicosatetraenoic acids in human intrauterine tissues using liquid chromatography / electrospray ionization tandem mass spectrometry.Anal Biochem.2007Jun 1; 365(1):40-51. Epub 2007 Mar 7

 

25.     Pearson T,Zhang J, Arya P, Warren AY, Ortori C, Fakis A, Khan RN, Barrett DA. Measurement of vasoactive metabolites (hydroxyleicosatetraenoic and epoxyeicosatrienoicacids ) in uterine tissues of normal and compromised human pregnancy.J Hypertens.28(12):2429-37,2010

 

26.     Chew E-H, Matthews CS,Zhang J,McCarroll AJ, Hagen T, Stevens MFG, Westwell AD, Bradshaw TD. Antitumor quinols: role of glutathione in modulating quinol-induced apoptosis and identification of putative cellular protein targets.Biochem Biophys Res Commun.2006Jul 21; 346(1):242-51. Epub 2006 May 26