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The Laboratory of Pathogeny Biology


The Laboratory of Pathogeny Biology has been teaching Medical Microbiology, Pathogeny Biology, Human Parasitology, Cell Biology and Pathogens related experiments for undergraduate and graduate students. Professor Jing Shenrong is in charge of the laboratory. The laboratory researches are funded by about two million yuan, including one National 863 Major Program of China, three Natural Nature Science Foundation of China, four Science Foundation of the Yunnan Province, China, one Talent Training of Kunming University of Science and Technology, and five cooperation foundation with companies. The lab has applied for more than ten patents, two of which have been authorized. More than 50 research papers (11 SCI) and one monograph have been published. The research of the laboratory focuses on the following aspects:

1. The Development of Viral Vaccines

For respiratory syncytial virus (RSV), the engineering vaccine based on G protein of RSV has been constructed and efficiently protects animals from RSV infection, which will be a candidate vaccine for RSV in clinical treatment.

For human papillomavirus (HPV), the lab has developed a system of production and purification for HPV bivalent vaccine (type 16 and 18) and assessed the safety and efficiency in animals, which laid a foundation on the application to the clinical experiments.



2. Viruses Research

The lab focuses on the research of zoonotic diseases, especially in the epidemiology of viruses and the spread across different species. The development of the cell culture and animal models for the study on viral replication, the reaction between virus and host cells, pathogenic mechanism and the prevention of viruses’ infection are also included.

3. Lactic acid bacteria liver vector vaccine

Lactic acid bacteria are recognized as a generally regarded as safe (GRAS) gram-positive bacterium, which benefits people’s health. Now, Lactic acid bacteria serve as a live vector vaccine to transmit exogenous gene expressed in host for inducing a special immune response against pathogenic antigen. The admission Lactic acid bacteria vector vaccine via mucosa will induce mucosal immunity, which will protect against pathogens infection.