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孔祥阳

发布时间:2015-03-13

 

孔祥阳教授、博士生导师、研究室负责人

 

毕业学校:

Texas A&M University  

                     

所学专业:

遗传学

 

所属教研室:

遗传学教研室

 

主要特长:  

分子生物学、遗传学、计算机科学和统计学等多学科的综合工作背景。近20年来从事的工作包括群体遗传学、分子遗传学、统计遗传学、生物信息和基因组学等方面的研究,及其在药物开发及疾病诊断上的应用。

 

研究方向:

疾病/药物遗传学,生物信息

 

在研项目:  

1.  性别发育的遗传机理;

2.  非吸烟因素引发慢性阻塞性肺病的遗传机理;

3.  结直肠癌异质性和影响肿瘤转移的基因组研究;

4.  基于二代测序的药物基因组检测技术。

 

研究内容:

遗传病临床检测/诊断;慢性病患病风险评估;肿瘤基因组异质性和转移,早期检测;

肠道宏基因组学和药物/营养干预;药物基因组学和个体化用药。

 

发表文章及专利:

1) 代表性论文12篇

[1]   Kong X, Cho MH, Anderson W, Coxson HO, Muller N, Washko G, Hoffman EA, Bakke P, Gulsvik A, Lomas DA. Genome-wide Association Study Identifies BICD1 as a Susceptibility Gene for Emphysema[J]. American journal of respiratory and critical care medicine, 2011, 183(1): 43 

影响因子:12.0 ;引用次数:51

[2]   Kong X, Murphy K, Raj T, He C, White P, Matise T. A combined linkage-physical map of the human genome[J]. The American Journal of Human Genetics, 2004, 75(6): 1143-1148

影响因子:11.2 ;引用次数:218

[3]Kong X, Matise T. MAP-O-MAT: internet-based linkage mapping[J].  Bioinformatics, 2005, 21(4): 557-559

影响因子:4.6 ;引用次数:36

[4]  Scott LJ, Muglia P, Kong XQ, Guan W, Flickinger M, Upmanyu R, Tozzi F, Li JZ, Burmeister M, Absher D. Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry[J]. Proceedings of the National Academy of Sciences, 2009, 106(18): 7501-7506

影响因子:10.8 ;引用次数:166

[5]  PILLAI SG, XIANGYANG K, EDWARDS LD, CHO MH, ANDERSON WH, COXSON HO, LOMAS DA, SILVERMAN EK. Loci Identified by Genome-wide Association Studies Influence Different Disease-related Phenotypes in Chronic Obstructive Pulmonary Disease[J]. American journal of respiratory and critical care medicine, 2010, 182(12): 1498-1505

影响因子:12.0 ;引用次数:69

[6]  Foreman MG, Kong X, DeMeo DL, Pillai SG, Hersh CP, Bakke P, Gulsvik A, Lomas DA, Litonjua AA, Shapiro SD. Polymorphisms in Surfactant Protein–D Are Associated with Chronic Obstructive Pulmonary Disease[J]. American Journal of Respiratory Cell and Molecular Biology, 2011, 44(3): 316

影响因子:4.2 ;引用次数:40

[7]  Cho MH, Boutaoui N, Klanderman BJ, Sylvia JS, Ziniti JP, Hersh CP, DeMeo DL, Hunninghake GM, Litonjua AA, Sparrow D, Lange C, WonS, MurphyJR, BeatyTH, ReganEA, MakeBJ, HokansonJE, CrapoJD, KongXY, AndersonWH, SingerRT, LomasDA,BakkeP,GulsvikA,PillaiSG, SilvermanE. Variants in FAM13A are associated with chronic obstructive pulmonary disease[J]. Nature genetics, 2010, 42(3): 200-202

影响因子:29.6  ;引用次数:134

[8]  Pillai SG, Ge D, Zhu G, Kong X,均等贡献), Shianna KV, Need AC, Feng S, Hersh CP, Bakke P, Gulsvik A. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci[J]. PLoS genetics, 2009, 5(3): e1000421

影响因子:9.4  ;引用次数:323

[9]  Song K, Nelson M, Aponte J, Manas E, Bacanu S, Yuan X, Kong X, Cardon L, Mooser V, Whittaker J. Sequencing of Lp-PLA2-encoding PLA2G7 gene in 2000 Europeans reveals several rare loss-of-function mutations[J]. The pharmacogenomics journal, 2011, 12(5): 425-431

影响因子:3.8  ;引用次数: 8

[10]Muglia P, Tozzi F, Galwey N, Francks C, Upmanyu R, Kong X, Antoniades A, Domenici E, Perry J, Rothen S. Genome-wide association study of recurrent major depressive disorder in two European case–control cohorts[J]. Molecular psychiatry, 2008, 15(6): 589-601

影响因子:15.1  ;引用次数:164

[11]Matise TC, Chen F, Chen W, Francisco M, Hansen M, He C, Hyland FC, Kennedy GC, Kong X, Murray SS. A second-generation combined linkage–physical map of the human genome[J]. Genome research, 2007, 17(12): 1783-1786

影响因子:13.8  ;引用次数: 179

[12]Saccone NL, Culverhouse RC, Schwantes-An T-H, Cannon DS, Chen X, Cichon S, Giegling I, Han S, Han Y, Keskitalo-Vuokko K, Kong X,. Multiple independent loci at chromosome 15q25. 1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD[J]. PLoS genetics, 2010, 6(8): e1001053

影响因子:9.4  ;引用次数: 157

 

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